Articles USTHB

Permanent URI for this collectionhttp://192.168.16.104:4000/handle/123456789/8953

Browse

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Synthesis, characterization, electrochemical studies and DFT calculations of amino acids ternary complexes of copper (II) with isonitrosoacetophenone. Biological activities
    (Elsevier, 2014) Tidjani-Rahmouni, Nabila; Bensiradj, Nour el Houda; Djebbar, Safia; Benali-Baitich, Ouassini
    Three mixed complexes having formula [Cu(INAP)L(H2O)2] where INAP = deprotonated isonitrosoacetophenone and L = deprotonated amino acid such as histidine, phenylalanine and tryptophan have been synthesized. They have also been characterized using elemental analyses, molar conductance, UV–Vis, IR and ESR spectra. The value of molar conductance indicates them to be non-electrolytes. The spectral studies support the binding of the ligands with two N and two O donor sites to the copper (II) ion, giving an arrangement of N2O2 donor groups. Density Functional Theory (DFT) calculations were applied to evaluate the cis and trans coordination modes of the two water molecules. The trans form was shown to be energetically more stable than the cis one. The ESR data indicate that the covalent character of the metal–ligand bonding in the copper (II) complexes increases on going from histidine to phenylalanine to tryptophan. The electrochemical behavior of the copper (II) complexes was determined by cyclic voltammetry which shows that the chelate structure and electron donating effects of the ligands substituent are among the factors influencing the redox potentials of the complexes. The antimicrobial activities of the complexes were evaluated against several pathogenic microorganisms to assess their antimicrobial potentials. The copper complexes were found to be more active against Gram-positive than Gram-negative bacteria
  • No Thumbnail Available
    Item
    New 2-pyrone-based hydrazones: Synthesis, spectral characterisation, UV–visible study and evaluation of the antiradicalar activity
    (Taylor & Francis, 2017) Oukacha-Hikem, Djamila; Makhloufi-Cheblia, Malika; Amar, Anissa; Bouherrou, Houria; Rachedi, Yahia; Meghezzi, Hacène; Silva, Artur M. S.; Hamdi, Maamar
    The synthesis of new 2-pyrone-based hydrazones has been prepared by the coupling of 6-methyl-2H-furo[3,2-c]pyran-3,4-dione with diazonium salts, obtained by diazotization of aniline derivatives. The structure of all compounds was established by spectroscopic methods, and the structure of the more stable conformer was theoretically confirmed by the potential energy profile analysis. The prepared 2-pyrone-based hydrazone dyes were acetylated and both groups of compounds showed moderate to good radical scavenging activity.